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61.
WM. F. Stein M. Dorthy Beck Arthur C. Hollister Jr. Earl Mortenson 《The Western journal of medicine》1951,75(2):94-97
The procedures used in the organization and operation of a special study on diarrheal diseases involving federal, state, and local agencies are outlined. The integration of such a project into a local routine program is discussed and the possible benefits derived by the various agencies are briefly evaluated. 相似文献
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Cloning and expression of the human substance K receptor and analysis of its role in mitogenesis. 总被引:1,自引:0,他引:1
R M Kris V South A Saltzman S Felder G A Ricca M Jaye K Huebner J Kagan C M Croce J Schlessinger 《Cell growth & differentiation》1991,2(1):15-22
The primary structure of the human substance K receptor was established from the sequences of complementary DNA clones isolated from a human jejunal complementary DNA library. It consists of 398 amino acids, including seven putative transmembrane regions. The gene for the human substance K receptor was localized to chromosome region 10p13-10q23, a region with frequent chromosomal abnormalities. The human substance K receptor was expressed in transfected NIH-3T3 cells lacking endogenous substance K receptors, and Scatchard analysis of 125I-labeled substance K binding indicates approximately 100,000 receptors/cell with a single dissociation constant of 12 nM. Covalent cross-linking experiments utilizing 125I-substance K and three different chemical cross-linking reagents (disuccinimidyl suberate, disuccinimidyl tartrate, or 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide-HCl) demonstrate an apparent molecular weight of 45,000, consistent with little or no N-linked glycosylation. The binding of substance K to its receptor on transfected cells led to a rapid increase in the production of total inositol phosphates and the release of Ca2+ from internal stores. Growth of the cells transfected with the human substance K receptor is stimulated by the addition of substance K to the medium to a level similar to 10% serum. Therefore, the human substance K receptor can function as a growth factor receptor when expressed in mouse 3T3 cells. 相似文献
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An analysis of restriction fragment length polymorphism (RFLP) using eight
residential insertion sequence (IS) elements as hybridization probes
reveals that the genome of resting bacteria is more dynamic than it was
long believed. Escherichia coli strains stored in agar stabs for up to 30
yr accumulate a genetic variation which is correlated to time of storage.
This spontaneous mutagenesis is often IS-specific, with particularly high
activity for IS5, and thus suggests that transpositional DNA rearrangements
are a major cause for the observed genetic polymorphism. The RFLP patterns
indicate a burst of IS30 transposition to occur occasionally. Mutation rate
is estimated by two different methods to roughly 10(-5) IS-related DNA
rearrangements per bacterial chromosome per hour of storage for the eight
IS elements studied. A pedigree derived from the RFLP data reveals that
populations had evolved independently in each stab and showed no signs of
convergence. Relics of an assumed ancestral population were still present
in the stab cultures, but the elder stabs provided mostly mutants. These
results indicate that cells placed under nutritional deprivation might have
a highly plastic genome and suggest that such plasticity might play an
adaptive role.
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